During an ordinary morning, the Fantastic Four and Namor interrupt Spider-Man in his heroic endeavors with terrifying news. The magnificent underwater city of Atlantis has disappeared and the heroes need Spider-Man's help to find it! Spider-Man accepts to take part in this uncertain mission because he doesn't want to disappoint the heroes... But when other superheroes start disappearing everywhere, Spidey realizes that if he wants to solve the mystery, this time he'll need a lot more than his superpowers... Along with some guest heroes (Ant-Man, Wasp, She-Hulk), author Mike Maihack sends Spider-Man into the wondrous world of the Quantum Realm!